-
"Post?translational modifications of vertebrate striated muscle myosin heavy chains"
2024 ▪
Cytoskeleton
-
"Structure of mavacamten-free human cardiac thick filaments within the sarcomere by cryoelectron tomography"
2024 ▪
Proceedings of the National Academy of Sciences
-
"Troponin Structural Dynamics in the Native Cardiac Thin Filament Revealed by Cryo Electron Microscopy"
2024 ▪
Journal of Molecular Biology
-
"A missense variant in the Z-disc protein ?-actinin 2: Evidence for a sarcomere protein at the nexus of thick and thin filament regulation"
2024 ▪
Biophysical Journal
Isabella Leite Coscarella;
P. Bryant Chase;
Jose R. Pinto;
Maicon Landim-Vieira;
Weikang Ma;
Bjorn C. Knollmann;
Thomas C. Irving;
Jeffrey Schmeckpeper;
Xuan Fang;
Payton A. Spran;
Aida Rahimi Kahmini;
M. Benjamin Shoemaker;
James B. Atkinson;
Peter M. Kekenes-Huskey;
Michelle C. Rodriguez Garcia;
-
"Cardiac troponin C N-helix deletion in mouse heart"
2024 ▪
Biophysical Journal
-
"Characterization of LV function using myocardial strain analysis in cardiac TnC-A8V mouse model"
2024 ▪
Biophysical Journal
-
"HCM- and DCM-associated TNNT2 sarcomeric variants induce divergent nucleus remodeling in human iPSC-CMs"
2024 ▪
Biophysical Journal
-
"In situ C-zone structure of Mavacamten-free human cardiac thick filaments by cryo-electron tomography"
2024 ▪
Biophysical Journal
-
"Disruption of Z-Disc Function Promotes Mechanical Dysfunction in Human Myocardium: Evidence for a Dual Myofilament Modulatory Role by Alpha-Actinin 2"
2023 ▪
International Journal of Molecular Sciences
Isabella Leite Coscarella;
P. Bryant Chase;
Jose R. Pinto;
Maicon Landim-Vieira;
Weikang Ma;
Bjorn C. Knollmann;
Thomas C. Irving;
Michelle Rodriguez Garcia;
Jeffrey Schmeckpeper;
Xuan Fang;
Payton A. Spran;
Shengyao Yuan;
Lin Qi;
Aida Rahimi Kahmini;
M. Benjamin Shoemaker;
James B. Atkinson;
Peter M. Kekenes-Huskey;
-
"Nucleus Mechanosensing in Cardiomyocytes"
2023 ▪
International Journal of Molecular Sciences
-
"Cardiac troponin T N-domain variant destabilizes the actin interface resulting in disturbed myofilament function"
2023 ▪
Proceedings of the National Academy of Sciences
Isabella Leite Coscarella;
P. Bryant Chase;
Jose R. Pinto;
Vitold E. Galkin;
Maicon Landim-Vieira;
Weikang Ma;
Taejeong Song;
Hosna Rastegarpouyani;
Henry Gong;
Sylvia J. P. Bogaards;
Stefan P. Conijn;
Coen A. C. Ottenheijm;
Hyun S. Hwang;
Maria Papadaki;
Bjorn C. Knollmann;
Sakthivel Sadayappan;
Thomas C. Irving;
-
"Abnormal kinetics of contraction caused by an ?-actinin 2 missense variant in the EF-3-4 hand domain in human myocardium"
2023 ▪
Biophysical Journal
Isabella Leite Coscarella;
P. Bryant Chase;
Jose R. Pinto;
Maicon Landim-Vieira;
Weikang Ma;
Bjorn C. Knollmann;
Thomas C. Irving;
Jeffrey Schmeckpeper;
Xuan Fang;
Aida Rahimi Kahmini;
M. Benjamin Shoemaker;
James B. Atkinson;
Peter M. Kekenes-Huskey;
Michelle C. Rodriguez Garcia;
Lili Wang;
-
"Computational modeling of cooperative regulation of both strands in thin filaments"
2023 ▪
Biophysical Journal
-
"Dissecting the mechanisms by which a pathogenic variant in cardiac TnT tail domain leads to disturbed myofilament performance"
2023 ▪
Biophysical Journal
P. Bryant Chase;
Jose R. Pinto;
Vitold E. Galkin;
Maicon Landim-Vieira;
Weikang Ma;
Taejeong Song;
Hosna Rastegarpouyani;
Henry Gong;
Coen A. C. Ottenheijm;
Maria Papadaki;
Bjorn C. Knollmann;
Sakthivel Sadayappan;
Thomas C. Irving;
Hyun Seok Hwang;
-
"HCM and DCM associated TNNT2 sarcomeric variants induce nucleus remodeling in human iPSC-CMs"
2023 ▪
Biophysical Journal
-
"Investigating the sarcolemma-sarcomere connection and force transmission in the heart"
2023 ▪
Biophysical Journal
-
"Protein densitometry profiling in mouse hearts carrying an HCM cardiac troponin T mutation"
2023 ▪
Biophysical Journal
-
"The structure of the junction region of the native cardiac thin filament"
2023 ▪
Biophysical Journal
-
"High-resolution cryo-EM structure of the junction region of the native cardiac thin filament in relaxed state"
2022 ▪
PNAS Nexus
-
"Post-translational modification patterns on ?-myosin heavy chain are altered in ischemic and nonischemic human hearts"
2022 ▪
eLife
-
"Author response: Post-translational modification patterns on ?-myosin heavy chain are altered in ischemic and nonischemic human hearts"
2022 ▪
-
"Hypertrophic and dilated cardiomyopathy-associatedTNNT2 pathogenic variants induce nucleus remodeling in hiPSC-CM models"
2022 ▪
Biophysical Journal
-
"Mechanism(s) of regulation of the cardiac thin filament: new perspectives for a longstanding enigma"
2022 ▪
Biophysical Journal
-
"Modeling force redevelopment as a response to thin filament activation time"
2022 ▪
Biophysical Journal
-
"Role of cardiac alpha-actinin 2 pathogenic variant in human myocardium mechanics"
2022 ▪
Biophysical Journal
P. Bryant Chase;
Jose R. Pinto;
Maicon Landim-Vieira;
Bjorn C. Knollmann;
Jeffrey Schmeckpeper;
M. Benjamin Shoemaker;
Michelle C. Rodriguez Garcia;
Lili Wang;
-
"The HCM I79N pathogenic variant in cardiac TNT induces thick filament malfunction and myofilament lattice rearrangement"
2022 ▪
Biophysical Journal
P. Bryant Chase;
Jose R. Pinto;
Maicon Landim-Vieira;
Weikang Ma;
Taejeong Song;
Henry Gong;
Coen A. C. Ottenheijm;
Bjorn C. Knollmann;
Sakthivel Sadayappan;
Thomas C. Irving;
Hyun Seok Hwang;
Maria Papadaki;
-
"Abstract P417: Cardiomyopathy-associated Variant In Troponin T Tail Domain Promotes Disruption Of Both Frank-starling Mechanism And Cardiac Myofilament Performance"
2021 ▪
Circulation Research
P. Bryant Chase;
Jose R. Pinto;
Maicon Landim-Vieira;
Weikang Ma;
Taejeong Song;
Bjorn C. Knollmann;
Sakthivel Sadayappan;
Thomas C. Irving;
Hyun Seok Hwang;
Coen Ottenheijm;
-
"Abstract P421: Analysis Of The Functional Relevance Of Human Beta-myosin Heavy Chain Post-translational Modifications"
2021 ▪
Circulation Research
-
"Abstract P432: Alpha-actinin 2 Missense Variant And Its Role In Cardiac Muscle Force Production And Diastolic Dysfunction"
2021 ▪
Circulation Research
P. Bryant Chase;
Jose R. Pinto;
Maicon Landim-Vieira;
Bjorn C. Knollmann;
Jeffrey Schmeckpeper;
Michelle C. Rodriguez Garcia;
Lili Wang;
Ben B Shoemaker;
-
"Mandibular muscle troponin of the Florida carpenter ant Camponotus floridanus: extending our insights into invertebrate Ca2+ regulation"
2021 ▪
Journal of Muscle Research and Cell Motility
P. Bryant Chase;
Jose R. Pinto;
Maicon Landim-Vieira;
Yun Shi;
Julia P. Bethea;
Hannah L. Hetzel-Ebben;
Ross J. Mayper;
Regan L. Williams;
Lauren E. Kessler;
Amanda M. Ruiz;
Kathryn Gargiulo;
Jennifer S. M. Rose;
Grayson Platt;
Brian K. Washburn;
-
"The structure of the native cardiac thin filament at systolic Ca 2+ levels"
2021 ▪
Proceedings of the National Academy of Sciences
-
"Conditional Knock-Out of Cardiac Myosin Light Chain Kinase Ameliorates Hypertrophic Cardiomyopathy Phenotype in a Murine Model"
2021 ▪
Biophysical Journal
-
"Genetic Variants and Post-Translational Modifications of Cardiac Troponin C: Insights from the Public Databases"
2021 ▪
Biophysical Journal
-
"Mandibular Muscle Troponin of the Florida Carpenter Ant Camponotus floridanus: Extending Our Insights into Invertebrate Ca2+ Regulation"
2021 ▪
Biophysical Journal
P. Bryant Chase;
Jose R. Pinto;
Maicon Landim-Vieira;
Yun Shi;
Julia P. Bethea;
Hannah L. Hetzel-Ebben;
Ross J. Mayper;
Regan L. Williams;
Lauren E. Kessler;
Amanda M. Ruiz;
Kathryn Gargiulo;
Jennifer S. M. Rose;
Grayson Platt;
Brian K. Washburn;
-
"Mechanical Force Rather Than Strong Binding Intermediates Extends Activation of Regulated Actin"
2021 ▪
Biophysical Journal
-
"Modulation of Cardiac Thin Filament Azimuthal Rigidity by Calcium and Cross-Bridges"
2021 ▪
Biophysical Journal
-
"Post-Translational Modifications in Human Beta Myosin Heavy Chain"
2021 ▪
Biophysical Journal
-
"Anomalous structural dynamics of minimally frustrated residues in cardiac troponin C triggers hypertrophic cardiomyopathy"
2021 ▪
Chemical Science
P. Bryant Chase;
Jose R. Pinto;
Vitold E. Galkin;
Maicon Landim-Vieira;
Jamie R. Johnston;
Michelle S. Parvatiyar;
Mayra A. Marques;
Guilherme A.P. de Oliveira;
Adolfo H. Moraes;
Jerson L. Silva;
Karissa M. Dieseldorff Jones;
Isela C. Valera;
Peter M. Kekenes-Huskey;
Bin Sun;
Elio A. Cino;
-
"A comprehensive guide to genetic variants and post-translational modifications of cardiac troponin C"
2020 ▪
Journal of Muscle Research and Cell Motility
-
"Mechanical contribution to muscle thin filament activation"
2020 ▪
Journal of Biological Chemistry
-
"Meta-analysis of cardiomyopathy-associated variants in troponin genes identifies loci and intragenic hot spots that are associated with worse clinical outcomes"
2020 ▪
Journal of Molecular and Cellular Cardiology
-
"Sexual dimorphism in cardiac transcriptome associated with a troponin C murine model of hypertrophic cardiomyopathy"
2020 ▪
Physiological Reports
-
"Calcium Regulates Average Time and not Velocity a Thin Filament Moves"
2020 ▪
Biophysical Journal
-
"Connecting Cardiac Sarcolemma Protein Content with Sarcomeric Function"
2020 ▪
Biophysical Journal
-
"Measurements of Actin Layer Lines in Permeabilized Heart Tissue Reveal New Structural Properties of the Cardiac Thin Filament"
2020 ▪
Biophysical Journal
-
"Osmotic Compression Influences Cross-Bridge Detachment Rate in Transgenic Hypertrophic Cardiomyopathy Variant Hctnt-I79N and Non-Transgenic Mouse Cardiac Muscle"
2020 ▪
Biophysical Journal
-
"Reduced Beta Myosin Heavy Chain K213 Acetylation and T215 Phosphorylation in Human Heart Failure"
2020 ▪
Biophysical Journal
-
"Sex Differences in Regulating the Cardiac Transcriptome within a Murine Model for Hypertrophic Cardiomyopathy"
2020 ▪
Biophysical Journal
-
"Familial Dilated Cardiomyopathy Associated With a Novel Combination of Compound Heterozygous TNNC1 Variants"
2020 ▪
Frontiers in Physiology
P. Bryant Chase;
Jose R. Pinto;
Maicon Landim-Vieira;
Jamie R. Johnston;
Weizhen Ji;
Emily K. Mis;
Joshua Tijerino;
Michele Spencer-Manzon;
Lauren Jeffries;
E. Kevin Hall;
David Panisello-Manterola;
Mustafa K. Khokha;
Engin Deniz;
Saquib A. Lakhani;
-
"The intrinsically disordered C terminus of troponin T binds to troponin C to modulate myocardial force generation"
2019 ▪
Journal of Biological Chemistry
P. Bryant Chase;
Jose R. Pinto;
Maicon Landim-Vieira;
Jamie R. Johnston;
Huan He;
David Gonzalez-Martinez;
Mayra A. Marques;
Guilherme A.P. de Oliveira;
Adolfo H. Moraes;
Anwar Iqbal;
Yael Wilnai;
Einat Birk;
Nili Zucker;
Jerson L. Silva;
-
"Supplementary Data for Publication Titled "Sex differences in regulating the cardiac transcriptome within a murine model for hypertrophic cardiomyopathy""
2019 ▪
-
"Cardiomyocyte nuclearity and ploidy: when is double trouble?"
2019 ▪
Journal of Muscle Research and Cell Motility
-
"Annulment of Cardiac Muscle Length-Dependent Force Activation in Transgenic Mice Bearing the HcTnT-I79N Mutation"
2019 ▪
Biophysical Journal
-
"Dynamic and Structural Allosteric Events between the D/E Linker and N-Domain of Cardiac Troponin C Reveal a Novel Mechanism for Cardiac Muscle Regulation"
2019 ▪
Biophysical Journal
P. Bryant Chase;
Jose R. Pinto;
Mayra A. Marques;
Guilherme A.P. de Oliveira;
Adolfo H. Moraes;
Jerson L. Silva;
Karissa M. Dieseldorff Jones;
Elio A. Cino;
Maicom Landim-Vieira;
-
"Thin Filament Regulation Blends Thermodynamic and Mechanical Mechanisms"
2019 ▪
Biophysical Journal
-
"The missing links within troponin"
2018 ▪
Archives of Biochemistry and Biophysics
-
"Structural and functional impact of troponin C-mediated Ca2+ sensitization on myofilament lattice spacing and cross-bridge mechanics in mouse cardiac muscle"
2018 ▪
Journal of Molecular and Cellular Cardiology
P. Bryant Chase;
Jose R. Pinto;
Maicon Landim-Vieira;
Jamie R. Johnston;
Weikang Ma;
Thomas C. Irving;
David Gonzalez-Martinez;
Olga Antipova;
Omar Awan;
-
"Aberrant Cardiac Muscle Mechanics in a Hypertrophic Cardiomyopathy Troponin T ILE79ASN Transgenic Mouse"
2018 ▪
Biophysical Journal
P. Bryant Chase;
Jose R. Pinto;
Maicon Landim-Vieira;
Bjorn C. Knollmann;
David Gonzalez-Martinez;
Hyun Seok Hwang;
Karissa M. Dieseldorff Jones;
Yeojung Koh;
-
"Cardiac Thin Filament-Mediated Calcium Sensitization Modulates Cross-Bridge Kinetics"
2018 ▪
Biophysical Journal
P. Bryant Chase;
Jose R. Pinto;
Maicon Landim-Vieira;
Jamie R. Johnston;
Weikang Ma;
Thomas C. Irving;
David Gonzalez-Martinez;
Omar Awan;
Olga A. Antipova;
-
"Clinical and Biophysical Characterization of a Mutation in the N-Helix Region of Cardiac Troponin C: Evidence for an Allosteric Mechanism of Contractile Dysfunction"
2018 ▪
Biophysical Journal
P. Bryant Chase;
Jose R. Pinto;
Maicon Landim-Vieira;
Jamie R. Johnston;
David Gonzalez-Martinez;
Mayra A. Marques;
Guilherme A.P. de Oliveira;
Adolfo H. Moraes;
Yael Wilnai;
Einat Birk;
Nili Zucker;
Jerson L. Silva;
-
"Is Thin Filament Movement Switched On and Off by a Thermodynamic Process Alone"
2018 ▪
Biophysical Journal
-
"Troponin through the looking-glass: emerging roles beyond regulation of striated muscle contraction"
2017 ▪
Oncotarget
-
"Hypertrophic Cardiomyopathy Cardiac Troponin C Mutations Differentially Affect Slow Skeletal and Cardiac Muscle Regulation"
2017 ▪
Frontiers in Physiology
-
"Pathogenesis of depression? and anxiety?like behavior in an animal model of hypertrophic cardiomyopathy"
2017 ▪
The FASEB Journal
-
"A Novel DCM-Associated Mutation in the N-Helix of Cardiac Troponin C Exhibits Impaired Contractile Kinetics and Reduced Ca 2+ -Sensitivity In Vitro"
2017 ▪
Biophysical Journal
-
"Abnormal Cardiac Cross-Bridge Kinetics in a Troponin T ILE79ASN Transgenic Mouse Model"
2017 ▪
Biophysical Journal
P. Bryant Chase;
Jose R. Pinto;
Maicon Landim-Vieira;
Bjorn C. Knollmann;
David Gonzalez-Martinez;
Hyun Seok Hwang;
Karissa M. Dieseldorff Jones;
Kwangjun Lee;
Yeojung Koh;
-
"Thin Filament-Mediated Modulation of Mouse Cardiac Cross-Bridge Kinetics by Ca 2+ -Sensitizing Mutation CTNC-A8V or Bepridil"
2017 ▪
Biophysical Journal
P. Bryant Chase;
Jose R. Pinto;
Maicon Landim-Vieira;
Jamie R. Johnston;
Weikang Ma;
Thomas C. Irving;
David Gonzalez-Martinez;
Omar Awan;
Olga A. Antipova;
Brittany Griffin;
-
"Will you still need me (Ca2+, TnT, and DHPR), will you still cleave me (calpain), when I'm 64?"
2016 ▪
Aging Cell
-
"Fluorescent Protein-Based Ca2+ Sensor Reveals Global, Divalent Cation-Dependent Conformational Changes in Cardiac Troponin C"
2016 ▪
PLoS ONE
-
"Simultaneous Measurement of Force and Lattice Spacing in Skinned Cardiac Fibers"
2016 ▪
Biophysical Journal
-
"Long Term Ablation of Protein Kinase A (PKA)-mediated Cardiac Troponin I Phosphorylation Leads to Excitation-Contraction Uncoupling and Diastolic Dysfunction in a Knock-in Mouse Model of Hypertrophic Cardiomyopathy"
2014 ▪
Journal of Biological Chemistry