Research Terms
This Lactobacillus supplement prevents Type 1 diabetes by preventing the onset of autoimmunity that leads to Type 1 diabetes. Type 1 diabetes represents approximately five to ten percent of all human diabetes and the Centers for Disease Control and Prevention estimate that between 500,000 to one million Americans are living with the disease. According to the Food and Agricultural Organization, probiotics are live microorganisms which, when administered in adequate amounts, confer a health benefit on the host. In recent years, much interest has been shown in the use of the lactic acid bacteria Lactobacilli as probiotic organisms and their potential for disease prevention in both humans and animals. Researchers at the University of Florida have developed unique probiotic compositions for alleviating Type 1 diabetes comprised of an effective amount of one or more Lactobacillus isolates.
Probiotic compositions as food additives that are useful in preventing or delaying the development of Type 1 diabetes
Type 1 diabetes, also known as immune-mediated, juvenile, or insulin-dependent diabetes mellitus, is a disease of children and adults for which there is no adequate means for prevention or cure. Lactic acid bacteria and bifidobacteria are the most common types of microbes used as probiotics and have emerged as two dominant groups negatively correlated with the onset of type 1 diabetes. University of Florida researchers have developed probiotic compositions consisting of Lactobacillus isolates that can be used as food additives (probiotics) to prevent or slow the development of type 1 diabetes.
This noninvasive device combines three technologies – an electrogastrogram (EGG), near infra-red sensors (NIRS), and a biopac skin microphone to observe intestinal acoustics – to determine a preterm infant’s readiness for enteral feeding. Feeding intolerance is common in preterm infants – approximately 1 out of 4 preterm infants experience difficulty with intake or digestion of formula or breast milk. Infants that are small or sick may need to get nutrition and fluids through a vein, but it is crucial for development that infants ingest and digest food. Therefore, enteral feeding, wherein food is administered into the stomach, is beneficial, but an infant first must demonstrate feeding readiness, the ability to safely ingest and digest food. Available methods to determine an infant’s feeding readiness use subjective (and occasionally invasive) indicators that rely heavily on individual clinical judgment to guide enteral feeding. If feeding is too aggressive, infants can develop necrotizing enterocolitis (NEC); if feeding is too conservative, infants may experience growth failure, intestinal atrophy, increased inflammation, and an increased chance of sepsis.
Researchers at the University of Florida have developed a noninvasive monitoring system for reliable and systematic assessment of feeding readiness in feeding-intolerant preterm infants, reducing enteral feeding risks associated with guidance by available subjective monitoring methods. Additionally, this device may be applicable in predicting feeding readiness in post-surgical patients of any age, as well as patients with other intestinal disorders.
Noninvasive device that systematically predicts feeding readiness in feeding-intolerant preterm infants
This device systematically evaluates feeding readiness by combining a near infra-red sensor (NIRS), biopac skin microphone (for intestinal acoustics), and an electrogastrogram (EGG) (for electrical activity of the bowel). This combination enables users to measure regional tissue oxygenation (via NIRS), analyze bowel sounds for objective interpretation of intestine activity associated with motility (via biopac skin microphone), and identify digestion states and persistent disturbances of stomach function (via EGG). By incorporating quantitative diagnostic information, the system can generate consistent feeding readiness scores. This will avoid the subjectivity present in available technologies and reduce the risks associated with enteral feeding in preterm infants and other patients with intestinal disorders, leading to improved neonatal and post-surgical outcomes.